Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | DHPS | P49366 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625109 | 0.96 | ALOX15 (0.39) | MAPTHCN4ALOX15CYP3A4CYP2D6 | |
| SCHEMBL9624723 | 0.92 | KDM4E (0.42) | MAPTALOX15CYP3A4BCHECYP2D6 | |
| Hydrochloric Acid SCHEMBL9624394 | 0.91 | KDM4E (0.42) | MAPTALOX15BCHECYP2D6DHPS | |
| SCHEMBL9623839 | 0.91 | ALDH1A1 (0.41) | MAPTALOX15CHRNA7KDM4EMAPK1 | |
| SCHEMBL9624625 | 0.87 | ALDH1A1 (0.41) | MAPTALOX15CHRNA7KDM4EMAPK1 | |
| SCHEMBL9625087 | 0.87 | MAPT (0.43) | MAPTHCN4ALOX15CYP3A4CHRNA7 | |
| SCHEMBL9624380 | 0.85 | MAPT (0.39) | MAPTHCN4ALOX15CYP3A4BCHE | |
| SCHEMBL9625211 | 0.84 | HCN4 (0.57) | MAPTHCN4ALOX15CYP3A4KDM4E | |
| Hydrochloric Acid SCHEMBL9624724 | 0.84 | CYP3A4 (0.40) | MAPTHCN4ALOX15CYP3A4BCHE | |
| SCHEMBL9624387 | 0.83 | MAPT (0.39) | MAPTHCN4ALOX15CYP3A4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |