Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 5/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GNRHR | P30968 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624372 | 0.90 | TERT (0.46) | TERTKDM4ECYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9624791 | 0.87 | DRD3 (0.56) | DRD3KDM4EHTR1ADRD4CYP2C9 | |
| SCHEMBL9624622 | 0.87 | GNRHR (0.46) | TERTDRD3DRD1KDM4EHTR1A | |
| SCHEMBL9625087 | 0.81 | MAPT (0.43) | DRD3KDM4EHTR1ADRD4MAPT | |
| SCHEMBL9623628 | 0.81 | HRH3 (0.42) | DRD3DRD1HTR1ADRD4MAPT | |
| SCHEMBL9624616 | 0.79 | CYP2D6 (0.44) | KDM4ECYP2D6CYP2C9CYP2C19RECQL | |
| SCHEMBL9624387 | 0.79 | MAPT (0.39) | KDM4EMAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL10519444 | 0.78 | SIGMAR1 (0.54) | DRD3DRD1MAPTHCN4CYP3A4 | |
| SCHEMBL10668796 | 0.78 | HCN4 (0.68) | DRD3DRD1KDM4EHTR1ADRD4 | |
| SCHEMBL10523499 | 0.77 | HDAC3 (0.44) | DRD3DRD1KDM4ENPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |