Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12074443 | 0.80 | L3MBTL1 (0.54) | L3MBTL1MAOBCYP2D6TSHRHIF1A | |
| SCHEMBL7193788 | 0.75 | L3MBTL1 (0.56) | L3MBTL1MAOBTSHRPOLBKDM4E | |
| SCHEMBL12434732 | 0.75 | L3MBTL1 (0.56) | L3MBTL1MAOBTSHRPOLBKDM4E | |
| SCHEMBL6551819 | 0.75 | L3MBTL1 (0.52) | L3MBTL1MAOBHRH3MEN1KMT2A | |
| SCHEMBL1460306 | 0.75 | GAA (0.69) | MAOBCYP2D6TSHRHIF1AOPRM1 | |
| SCHEMBL12573567 | 0.75 | GAA (0.69) | MAOBCYP2D6TSHRHIF1AOPRM1 | |
| SCHEMBL8223804 | 0.75 | GAA (0.69) | MAOBCYP2D6TSHRHIF1AOPRM1 | |
| Methane SCHEMBL10647504 | 0.73 | L3MBTL1 (0.44) | L3MBTL1MAOBCYP2D6TSHRHIF1A | |
| SCHEMBL6979453 | 0.73 | GAA (0.71) | MAOBOPRM1KDM4EMEN1KMT2A | |
| SCHEMBL1205842 | 0.73 | GAA (0.71) | MAOBOPRM1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |