Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PRF1 | P14222 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624261 | 0.93 | HCN4 (0.44) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9624084 | 0.89 | MAPT (0.38) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL10400953 | 0.85 | MAPT (0.39) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9624291 | 0.84 | SMPD1 (0.36) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9624788 | 0.82 | SMPD1 (0.38) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9624153 | 0.82 | MTNR1A (0.41) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9624143 | 0.82 | HCN4 (0.41) | MAPTHCN4CYP3A4ALOX15MAOB | |
| SCHEMBL9624219 | 0.81 | MAPT (0.45) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| Hydrochloric Acid SCHEMBL9624526 | 0.81 | CYP3A4 (0.46) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9625682 | 0.80 | PRKCB (0.35) | MAPTSMPD1DRD2DRD3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |