Bromide

Bromide

SCHEMBL9625797

Br.CCCCCCCCCCCCCCCCN1CSc2ccccc21

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A known ✓ P08908 1/20 0.38
ALDH1A1 P00352 4/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C19 P33261 1/20 0.45
LMNA P02545 3/20 0.42
KDM4E B2RXH2 1/20 0.42
KDM1A O60341 1/20 0.41
PDF Q9HBH1 2/20 0.40
CES1 P23141 2/20 0.40
CDC25A P30304 1/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
HTT P42858 1/20 0.39
EEF2K O00418 1/20 0.38
ALDH2 P05091 1/20 0.38
ALDH3A1 P30838 1/20 0.38
TP53 P04637 1/20 0.37
MAPT P10636 1/20 0.37
FAAH O00519 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL9694372 1.00 ALDH1A1 (0.45) ALDH1A1CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL9064444 0.98 LMNA (0.43) ALDH1A1CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL9722988 0.98 LMNA (0.43) ALDH1A1CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL9037704 0.98 LMNA (0.43) ALDH1A1CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL29306541 0.98 LMNA (0.43) ALDH1A1CYP1A2CYP2D6CYP2C19LMNA
Iodide SCHEMBL9038446 0.97 LMNA (0.42) ALDH1A1CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL4304928 0.97 KDM1A (0.43) ALDH1A1CYP1A2CYP2D6CYP2C19LMNA
Bromide SCHEMBL9694632 0.94 KDM1A (0.47) ALDH1A1CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL9715453 0.92 KDM1A (0.48) ALDH1A1CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL29878442 0.92 KDM1A (0.48) ALDH1A1CYP1A2CYP2D6CYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5143917-A Cationic tensides for controlling infections MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) 1992-09-01 US disclosed
US-5133973-A Quaternary Ammonium Cationic Surfactants, Antimetabolites MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) 1992-07-28 US disclosed
US-5118808-A Pharmaceutical preparations MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) 1992-06-02 US disclosed
US-5112844-A Micelles MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) 1992-05-12 US disclosed
US-5110929-A Quaternization of pyrazine compounds MEDICE CHAM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) 1992-05-05 US disclosed
US-5057518-A Substituted n-alkylpyrimidinium salts for absorbing hydrophobic drugs MEDICE HEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) 1991-10-15 US disclosed
US-5051435-A Micelles of triazolium compounds as cationic surfactants MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) 1991-09-24 US disclosed
US-5045530-A Conprising a micelle or a vesicle of a cationic teniside based on a hydrophobic alkyl-substituted pyridinium compound and a hydrophobic drug; drug delivery; skin disorders MEDICI CHEM.-PHARM. FABRIK PUTTER GMBH (DE) 1991-09-03 US disclosed
US-4999435-A Cationic Surfactants, Drugs, Immunoassay MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) 1991-03-12 US disclosed
US-4965357-A CATIONIC TENSIDES, ANTIMETABOLITES MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) 1990-10-23 US disclosed
US-4894454-A BACTERICIDES MEDICE CHEM.-PHARM. FABRIK, PUTTER GMBH & CO., KG (DE) 1990-01-16 US disclosed
US-4882435-A CATIONIC TENSIDES; THIADIAZOLIUM SALTS MEDICE CHEM.-PHARM. FABRIK (DE) 1989-11-21 US disclosed
US-4877883-A CATIONIC SURFACTANTS MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) 1989-10-31 US disclosed
US-4874850-A CATIONIC TENSIDES IN MICELLES WITH HYDROPHOBIC PEPTIDES; DRUG DELIVERY MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. (DE) 1989-10-17 US disclosed
US-4870174-A CATIONIC SURFACTANTS, SMALL CRITICAL MICELLE CONCENTRATIONS MEDICE CHEM.-PHARM. FABRIK (DE) 1989-09-26 US disclosed