Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 10/20 | 0.42 |
| ▸ | RXRB | P28702 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 10/20 | 0.41 |
| ▸ | RARG | P13631 | 9/20 | 0.41 |
| ▸ | RXRG | P48443 | 4/20 | 0.41 |
| ▸ | RARA | P10276 | 8/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10452939 | 0.79 | RARG (0.70) | RXRARXRBNPC1RAB9ARARB | |
| SCHEMBL10452157 | 0.79 | RARG (0.70) | RXRARXRBNPC1RAB9ARARB | |
| SCHEMBL10452940 | 0.79 | RARG (0.70) | RXRARXRBNPC1RAB9ARARB | |
| SCHEMBL12620671 | 0.78 | RXRA (0.42) | RXRARXRBNPC1RAB9AMAPT | |
| SCHEMBL10452950 | 0.77 | RARG (0.54) | RXRARXRBNPC1RAB9ARARB | |
| SCHEMBL10452949 | 0.77 | RARG (0.54) | RXRARXRBNPC1RAB9ARARB | |
| SCHEMBL4709597 | 0.77 | CCR2 (0.35) | HSD17B10AKR1B1PDK2KMT2A | |
| SCHEMBL9860643 | 0.76 | RARG (0.53) | RXRARXRBNPC1RAB9ARARB | |
| SCHEMBL22106247 | 0.76 | RXRA (0.48) | RXRARXRBNPC1RAB9ARARB | |
| SCHEMBL9483506 | 0.76 | RARB (0.67) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0339521-B1 | PROCESS FOR MANUFACTURING TETRALIN DERIVATIVES, AND TETRALIN DERIVATIVES | BASF Aktiengesellschaft (DE) | 1992-03-18 | — | — | EP | claimed |
| EP-0339521-A1 | Process for manufacturing tetralin derivatives, and tetralin derivatives | BASF Aktiengesellschaft (DE) | 1989-11-02 | — | — | EP | claimed |
| EP-0339521-B1 | PROCESS FOR MANUFACTURING TETRALIN DERIVATIVES, AND TETRALIN DERIVATIVES | BASF Aktiengesellschaft (DE) | 1992-03-18 | — | — | EP | disclosed |
| US-4950369-A | Preparation of tetralin derivatives, and novel tetralin derivatives | BASF AKTIENGESELLSCHAFT (DE) | 1990-08-21 | — | — | US | disclosed |
| EP-0339521-A1 | Process for manufacturing tetralin derivatives, and tetralin derivatives | BASF Aktiengesellschaft (DE) | 1989-11-02 | — | — | EP | disclosed |