Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trigonelline SCHEMBL679317 | 0.81 | NNMT (0.68) | NNMTUSP2APOBEC3AAPOBEC3GHDAC8 | |
| SCHEMBL700182 | 0.81 | NNMT (0.68) | NNMTUSP2APOBEC3AAPOBEC3GHDAC8 | |
| Trigonelline SCHEMBL29581532 | 0.81 | NNMT (0.68) | NNMTUSP2APOBEC3AAPOBEC3GHDAC8 | |
| Trigonelline SCHEMBL195666 | 0.79 | USP2 (1.00) | NNMTUSP2APOBEC3AAPOBEC3GHDAC8 | |
| Trigonellamide SCHEMBL132244 | 0.79 | NNMT (1.00) | NNMTUSP2APOBEC3AAPOBEC3GHDAC8 | |
| Hydrochloric Acid SCHEMBL2293932 | 0.79 | NNMT (0.66) | NNMTUSP2APOBEC3AAPOBEC3GHDAC8 | |
| Trigonelline SCHEMBL29561369 | 0.79 | USP2 (1.00) | NNMTUSP2APOBEC3AAPOBEC3GHDAC8 | |
| Trigonelline SCHEMBL5310723 | 0.79 | NNMT (0.66) | NNMTUSP2APOBEC3AAPOBEC3GHDAC8 | |
| Trigonelline SCHEMBL5013564 | 0.79 | NNMT (0.66) | NNMTUSP2APOBEC3AAPOBEC3GHDAC8 | |
| Trigonelline SCHEMBL15361649 | 0.79 | NNMT (0.66) | NNMTUSP2APOBEC3AAPOBEC3GHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0366171-B1 | NUCLEOSIDE DERIVATIVES | NYCOMED AS (NO) | 1992-05-06 | — | — | EP | disclosed |
| EP-0437527-A1 | NUCLEOSIDE DERIVATIVES | NYCOMED AS (NO) | 1991-07-24 | — | — | EP | disclosed |
| WO-1990004603-A1 | NUCLEOSIDE DERIVATIVES | NYCOMED AS (NO) | 1990-05-03 | — | — | WO | disclosed |
| EP-0366171-A1 | Nucleoside derivatives | NYCOMED AS (NO) | 1990-05-02 | — | — | EP | disclosed |