Trigonellamide

Trigonellamide

SCHEMBL132244

C[n+]1cccc(C(N)=O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NNMT P40261 1/20 1.00
USP2 O75604 1/20 0.66
APOBEC3A P31941 2/20 0.53
APOBEC3G Q9HC16 2/20 0.53
L3MBTL1 Q9Y468 2/20 0.49
NPSR1 Q6W5P4 1/20 0.49
MAPT P10636 3/20 0.48
PARP1 P09874 2/20 0.48
TSHR P16473 2/20 0.48
POLB P06746 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2C19 P33261 1/20 0.48
RECQL P46063 1/20 0.48
BLM P54132 1/20 0.48
PMP22 Q01453 1/20 0.48
HSD17B10 Q99714 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
HDAC8 Q9BY41 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trigonellamide SCHEMBL5145685 0.98 NNMT (0.96) NNMTUSP2APOBEC3AAPOBEC3GL3MBTL1
Trigonellamide SCHEMBL15903434 0.98 NNMT (0.96) NNMTUSP2APOBEC3AAPOBEC3GL3MBTL1
Trigonellamide SCHEMBL4082736 0.98 NNMT (0.96) NNMTUSP2APOBEC3AAPOBEC3GL3MBTL1
Trigonellamide SCHEMBL16295415 0.91 NNMT (0.83) NNMTUSP2APOBEC3AAPOBEC3GL3MBTL1
Trigonelline SCHEMBL679317 0.81 NNMT (0.68) NNMTUSP2APOBEC3AAPOBEC3GTSHR
SCHEMBL700182 0.81 NNMT (0.68) NNMTUSP2APOBEC3AAPOBEC3GTSHR
Trigonelline SCHEMBL29581532 0.81 NNMT (0.68) NNMTUSP2APOBEC3AAPOBEC3GTSHR
Trigonelline SCHEMBL5310723 0.79 NNMT (0.66) NNMTUSP2APOBEC3AAPOBEC3GTSHR
Trigonelline SCHEMBL195666 0.79 USP2 (1.00) NNMTUSP2APOBEC3AAPOBEC3GTSHR
Hydrochloric Acid SCHEMBL2293932 0.79 NNMT (0.66) NNMTUSP2APOBEC3AAPOBEC3GTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1011 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
US-12616738-B2 Solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid NOVO NORDISK A/S (DK) 2026-05-05 US claimed
US-20260090969-A1 COMPOSITIONS THAT PROTECT CELLS FROM OXIDATIVE AND MITOCHONDRIAL STRESS Nuchido Limited (GB) 2026-04-02 US claimed
US-12584924-B2 Compositions and methods for diagnosing and treating chronic kidney disease SOCIETE DES PRODUITS NESTLE S.A. (CH) 2026-03-24 US claimed
US-20250213549-A1 COMPOSITION COMPRISING NICOTINAMIDE, NICOTINAMIDE PRECURSORS, NICOTINAMIDE METABOLITES OR COMBINATIONS THEREOF FOR PREVENTING OR REDUCING ONE OR MORE POST-ACUTE SYMPTOMS OF INFECTIOUS DISEASES CONARIS RESEARCH INSTITUTE AG (DE) 2025-07-03 US claimed
US-12292445-B2 Methods of selecting subjects for treatment with metabolomic modulators THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-05-06 US claimed
CN-119936223-A Metabolic marker for diagnosing or monitoring gastric cancer, screening method and application thereof 武汉迈特维尔医学科技有限公司 2025-05-06 CN claimed
CN-119837874-A Application of 1-methylnicotinamide in preparation of medicine for treating necrotizing enterocolitis 重庆医科大学附属儿童医院 2025-04-18 CN claimed
CN-119816897-A Multiple study assessment 普罗科技有限公司 2025-04-11 CN claimed
CN-119147681-B Method for detecting water-soluble vitamin metabolites in plants 北京大学现代农业研究院 2025-02-21 CN claimed
WO-2007074406-A2 FORMULATIONS FOR TREATMENT OF LIPOPROTEIN ABNORMALITIES COMPRISING A STATIN A STATIN AND A METHYLNICOTINAMIDE DERIVATIVE PHARMENA NORTH AMERICA INC. (CA) 2007-07-05 WO claimed
CN-1905875-A The use of quaternary pyridinium salts as vasoprotective agents PHARMENA SP Z O O (PL) 2007-01-31 CN claimed
US-20070021379-A1 Methylnicotinamide derivatives and formulations for treatment of lipoprotein abnormalities PHARMENA NORTH AMERICA INC. (CA) 2007-01-25 US claimed
EP-1713480-A2 THE USE OF QUATERNARY PYRIDINIUM SALTS AS VASOPROTECTIVE AGENTS Pharmena Sp Zo.o. (PL) 2006-10-25 EP claimed
WO-2006024545-A1 FUSED BICYCLIC NATURAL COMPOUNDS AND THEIR USE AS INHIBITORS OF PARP AND PARP-MEDIATED INFLAMMATORY PROCESSES STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2006-03-09 WO claimed
WO-2005067927-A2 THE USE OF QUATERNARY PYRIDINIUM SALTS AS VASOPROTECTIVE AGENTS PHARMENA SP Z O.O. (PL) 2005-07-28 WO claimed
EP-1147086-B1 COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES TECHNICAL UNIVERSITY OF LODZ (PL) 2005-03-30 EP claimed
EP-1147086-A1 COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES Technical University of Lodz (PL) 2001-10-24 EP claimed
WO-2000040559-A1 COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES TECHNICAL UNIVERSITY OF LODZ (PL) 2000-07-13 WO claimed
EP-0181172-A2 Cephalosporin antibiotics GLAXO GROUP LIMITED (GB) 1986-05-14 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260090969-A1 COMPOSITIONS THAT PROTECT CELLS FROM OXIDATIVE AND MITOCHONDRIAL STRESS NLN, TFAM, CYP27B1 NNMT 50/4885USP2 4863/4885APOBEC3A 4703/4885
US-12616738-B2 Solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid SLC5A1, GLP1R, SLC5A2 NNMT 83/4885USP2 1769/4885APOBEC3A 4868/4885
US-20070021379-A1 Methylnicotinamide derivatives and formulations for treatment of lipoprotein abnormalities HMGCR, NAMPT, NNMT NNMT 3/4885USP2 4357/4885APOBEC3A 4274/4885
US-12584924-B2 Compositions and methods for diagnosing and treating chronic kidney disease GLS, AADAT, FGF23 NNMT 232/4885USP2 1729/4885APOBEC3A 1393/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.