Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9625636 | 0.84 | SMN1; SMN2 (0.40) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| Oxalic Acid SCHEMBL9625360 | 0.78 | RIPK1 (0.39) | DPP4DPP7KDM4ETDP1ALDH1A1 | |
| SCHEMBL27926032 | 0.77 | ACP3 (0.51) | HTR2AHTR2CHTR2BEPHX1MEN1 | |
| SCHEMBL28245991 | 0.76 | MEN1 (0.50) | HTR2AHTR2CHTR2BEPHX1MEN1 | |
| SCHEMBL9625078 | 0.73 | RIPK1 (0.41) | DPP4DPP7KDM4ETDP1CYP1A2 | |
| Oxalic Acid SCHEMBL9626272 | 0.71 | ANPEP (0.43) | EPHX1CYP1A2CYP3A4SMN1; SMN2 | |
| SCHEMBL2033126 | 0.71 | HTR2A (0.60) | HTR2AHTR2CHTR2BEPHX1DPP4 | |
| SCHEMBL2034430 | 0.71 | HTR2A (0.60) | HTR2AHTR2CHTR2BEPHX1DPP4 | |
| SCHEMBL2033122 | 0.71 | HTR2A (0.60) | HTR2AHTR2CHTR2BEPHX1DPP4 | |
| SCHEMBL29478428 | 0.71 | HTR2A (0.60) | HTR2AHTR2CHTR2BEPHX1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322391-B1 | NEW PHENYLALKYLAMINE DERIVATIVES | AKTIEBOLAGET ASTRA (SE) | 1992-03-25 | — | — | EP | disclosed |