Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625078 | 0.96 | RIPK1 (0.41) | RIPK1TDP1KDM4EKIF11DPP4 | |
| Oxalic Acid SCHEMBL9625636 | 0.87 | SMN1; SMN2 (0.40) | RIPK1KDM4EKIF11MMP8ALDH1A1 | |
| Oxalic Acid SCHEMBL9625441 | 0.86 | DPP4 (0.44) | KDM4EKIF11DPP4DPP7PPARG | |
| Oxalic Acid SCHEMBL9626820 | 0.84 | HPGD (0.38) | RIPK1KDM4EKIF11HPGDBLM | |
| Oxalic Acid SCHEMBL9625536 | 0.84 | FFAR1 (0.37) | RIPK1KDM4EKIF11HPGDALDH1A1 | |
| Oxalic Acid SCHEMBL9625660 | 0.83 | DPP4 (0.39) | KDM4EDPP4DPP7MMP12CTBP2 | |
| Oxalic Acid SCHEMBL9624956 | 0.82 | BLM (0.35) | RIPK1KDM4EKIF11DPP4DPP7 | |
| Oxalic Acid SCHEMBL9625642 | 0.82 | RIPK1 (0.43) | RIPK1TDP1KDM4EPPARGHPGD | |
| Oxalic Acid SCHEMBL9625351 | 0.82 | TDP1 (0.45) | RIPK1TDP1KDM4EPPARGMMP2 | |
| Oxalic Acid SCHEMBL9626263 | 0.78 | HTR2A (0.46) | TDP1KDM4EDPP4DPP7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1023478-C | Novel compounds | ASTRA AB (SE) | 1994-01-12 | — | — | CN | disclosed |
| EP-0322391-B1 | NEW PHENYLALKYLAMINE DERIVATIVES | AKTIEBOLAGET ASTRA (SE) | 1992-03-25 | — | — | EP | disclosed |
| CN-1034710-A | New compound | ASTRA AB (SE) | 1989-08-16 | — | — | CN | disclosed |
| EP-0322391-A1 | New phenylalkylamine derivatives | AKTIEBOLAGET ASTRA (SE) | 1989-06-28 | — | — | EP | disclosed |