SCHEMBL9627399

SCHEMBL9627399

CCOc1ccc2c(c1)C(=O)C(C)=C(Cl)C2=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
KMT2A Q03164 3/20 0.43
CHRNA7 P36544 1/20 0.43
ALDH1A1 P00352 2/20 0.43
GAA P10253 2/20 0.43
KDM4E B2RXH2 1/20 0.43
HPGD P15428 1/20 0.43
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
CSNK2A2 P19784 1/20 0.41
CSNK2B P67870 1/20 0.41
CSNK2A1 P68400 1/20 0.41
CSNK2A3 Q8NEV1 1/20 0.41
RXRA P19793 1/20 0.41
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
ESR2 Q92731 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10883121 0.83 MAPT (0.70) MAPTL3MBTL1KMT2ACHRNA7ALDH1A1
SCHEMBL9627734 0.81 TOP1 (0.56) MAOAMAOB
SCHEMBL9627608 0.81 CDC25A (0.56) MAPTL3MBTL1KMT2ACHRNA7ALDH1A1
SCHEMBL2268303 0.78 MAPT (0.64) MAPTL3MBTL1KMT2ACHRNA7ALDH1A1
SCHEMBL9643489 0.78 MAPT (0.59) MAPTL3MBTL1KMT2ACHRNA7ALDH1A1
SCHEMBL10887519 0.77 MAPT (0.67) MAPTL3MBTL1KMT2ACHRNA7ALDH1A1
SCHEMBL11367478 0.77 MAPT (0.62) MAPTL3MBTL1KMT2ACHRNA7ALDH1A1
SCHEMBL9429530 0.76 MAPT (0.60) MAPTL3MBTL1KMT2ACHRNA7ALDH1A1
SCHEMBL10525629 0.75 MAPT (0.52) MAPTL3MBTL1KMT2ACHRNA7ALDH1A1
SCHEMBL9627540 0.75 MAPT (0.49) MAPTL3MBTL1KMT2ACHRNA7ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5155132-A Nonsteroidal antiinflammatory agents; treating psoriasis SYNTEX (U.S.A.) INC. (US) 1992-10-13 US disclosed
US-5134161-A Enzyme inhibitors for skin disorders, antiinflammatory agents SYNTEX (U.S.A.) INC. (US) 1992-07-28 US disclosed
US-5089657-A Topical antiinflammatory agents SYNTEX (U.S.A.) INC. (US) 1992-02-18 US disclosed
US-4786652-A TOPICAL ADMINISTRATION SYNTEX (U.S.A.) INC. (US) 1988-11-22 US disclosed
EP-0282006-A1 Naphtalene anti-psoriatic agents SYNTEX (U.S.A.) INC. (US) 1988-09-14 EP disclosed
EP-0282056-A2 Naphthalene anti-psoriatic agents SYNTEX (U.S.A.) INC. (US) 1988-09-14 EP disclosed
US-4758587-A Naphthalene anti-psoriatic agents SYNTEX (U.S.A.) INC. (US) 1988-07-19 US disclosed