Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | IDE | P14735 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627670 | 0.95 | ABCB11 (0.59) | ABCB11ALOX15KDM4EHSD17B10HTT | |
| SCHEMBL9643337 | 0.92 | ABCB11 (0.70) | ABCB11ALOX15KDM4EHSD17B10HTT | |
| SCHEMBL9654917 | 0.84 | ABCB11 (0.50) | ABCB11ALOX15KDM4EGAAMAPT | |
| SCHEMBL9642519 | 0.84 | ABCB11 (0.59) | ABCB11ALOX15KDM4EHSD17B10HTT | |
| SCHEMBL9643229 | 0.84 | ABCB11 (0.59) | ABCB11ALOX15KDM4EHSD17B10HTT | |
| SCHEMBL9643471 | 0.83 | ABCB11 (0.59) | ABCB11ALOX15KDM4EHSD17B10HTT | |
| SCHEMBL9641671 | 0.83 | ABCB11 (0.59) | ABCB11ALOX15KDM4EHSD17B10HTT | |
| SCHEMBL9657151 | 0.83 | ABCB11 (0.46) | ABCB11ALOX15KDM4EGAAMAPT | |
| SCHEMBL9627611 | 0.83 | KDM4E (0.50) | ABCB11KDM4EHSD17B10HTTGAA | |
| SCHEMBL9643362 | 0.82 | ABCB11 (0.58) | ABCB11KDM4EMAPTMAOBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |