Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.48 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9658181 | 0.89 | ABCC1 (0.48) | TDO2ABCC1CHEK1FGFR1CDK4 | |
| SCHEMBL9628456 | 0.87 | ABCC1 (0.45) | ABCC1ABCB1MAPTMEN1POLB | |
| SCHEMBL8922452 | 0.80 | CDK4 (0.51) | TDO2ABCC1CHEK1FGFR1CDK4 | |
| SCHEMBL9627412 | 0.80 | EP300 (0.48) | IDO1HPGDALDH1A1CYP3A4MAPT | |
| SCHEMBL9629506 | 0.80 | ADORA1 (0.47) | CHEK1HPGDALDH1A1MAPTMEN1 | |
| SCHEMBL9656557 | 0.79 | PDE4B (0.50) | TDO2CHEK1FGFR1CDK4CCNA2 | |
| Aucuparin SCHEMBL11223391 | 0.76 | SMPD3 (0.57) | ABCC1ERN1MAPTMEN1POLB | |
| SCHEMBL9971889 | 0.76 | ALOX5 (0.54) | HPGDALDH1A1CYP3A4MAPTCYP2C9 | |
| SCHEMBL30966839 | 0.74 | PDE4B (0.62) | TDO2ABCC1IDO1MAPTBACE1 | |
| SCHEMBL9657676 | 0.74 | PDE4B (0.45) | TDO2CHEK1FGFR1CDK4CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |