Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.52 |
| ▸ | MIF | P14174 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | GLS | O94925 | 2/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10257134 | 0.88 | HRH3 (0.60) | HRH3GABRA1GABRB2MIFMTNR1A | |
| SCHEMBL17761389 | 0.88 | HRH3 (0.56) | HRH3GABRA1GABRB2MTNR1AGLS | |
| SCHEMBL13802286 | 0.86 | FFAR1 (0.56) | HRH3GABRA1GABRB2MTNR1AGLS | |
| Hydrochloric Acid SCHEMBL9118102 | 0.83 | HRH3 (0.49) | HRH3GABRA1GABRB2MTNR1AGLS | |
| SCHEMBL10256487 | 0.82 | HRH3 (0.59) | HRH3GABRA1GABRB2MTNR1AGLS | |
| SCHEMBL7297149 | 0.81 | GABRA1 (0.47) | HRH3GABRA1GABRB2MIFMTNR1A | |
| SCHEMBL30637096 | 0.80 | ATM (0.60) | MIFMTNR1AATMLMNAABCB1 | |
| SCHEMBL9117533 | 0.80 | HRH3 (0.63) | HRH3GABRA1GABRB2MTNR1AGLS | |
| SCHEMBL14457195 | 0.79 | FFAR1 (0.42) | HRH3ITGB3ITGA2BTP53PPARD | |
| SCHEMBL7289417 | 0.78 | GLS (0.57) | HRH3GABRA1GABRB2MTNR1AGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281261-B1 | 3-AMINOMETHYL DERIVATIVES OF INDANE, INDOLINE AND DIHYDROBENZOFURANE AND DIHYDROBENZOTHIOPHENE | H. LUNDBECK A/S (DK) | 1992-05-06 | — | — | EP | disclosed |
| US-4946863-A | CNS-affecting 6-oxy-3-aminomethyl indanes, compositions thereof, and method of treating therewith | H. LUNDBECK A/S (DK) | 1990-08-07 | — | — | US | disclosed |
| US-4847254-A | CNS affecting 5-oxy-3-aminomethyl-dihydro-benzofurans and benzothiophenes | H. LUNDBECK A/S (DK) | 1989-07-11 | — | — | US | disclosed |
| EP-0281261-A2 | 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene | H. LUNDBECK A/S (DK) | 1988-09-07 | — | — | EP | disclosed |