Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.34 |
| ▸ | TUBB | P07437 | 2/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627448 | 1.00 | ABCB11 (0.72) | ABCB11SIRT1ALOX5LMNAKDM4E | |
| SCHEMBL9628133 | 0.90 | ABCB11 (0.61) | ABCB11SIRT1ALOX5LMNAKDM4E | |
| SCHEMBL9629384 | 0.90 | ABCB11 (0.65) | ABCB11SIRT1ALOX5LMNAKDM4E | |
| SCHEMBL9627592 | 0.86 | ABCB11 (0.51) | ABCB11ALOX5LMNAKDM4ESMN1; SMN2 | |
| Lonapalene SCHEMBL120134 | 0.85 | ABCB11 (1.00) | ABCB11LMNAKDM4ESMN1; SMN2HTT | |
| SCHEMBL9627987 | 0.85 | ABCB11 (0.50) | ABCB11ALOX5KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL9628241 | 0.84 | KDM4E (0.50) | ABCB11ALOX5KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL9641851 | 0.83 | ABCB11 (0.97) | ABCB11LMNAKDM4ESMN1; SMN2HTT | |
| SCHEMBL9642681 | 0.83 | ABCB11 (0.97) | ABCB11LMNAKDM4ESMN1; SMN2HTT | |
| SCHEMBL9643774 | 0.82 | ABCB11 (0.81) | ABCB11LMNAKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |