Lonapalene

Lonapalene

SCHEMBL120134

COc1c(OC)c(OC(C)=O)c2cc(Cl)ccc2c1OC(C)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB11 O95342 1/20 1.00
MAPT P10636 3/20 0.41
HTT P42858 2/20 0.41
KDM4E B2RXH2 2/20 0.41
TP53 P04637 1/20 0.41
GAA P10253 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TUBB4A P04350 1/20 0.40
TUBB P07437 1/20 0.40
TUBA3C P0DPH7 1/20 0.40
TUBA1B P68363 1/20 0.40
TUBA4A P68366 1/20 0.40
TUBB4B P68371 1/20 0.40
TUBB3 Q13509 1/20 0.40
TUBB2A Q13885 1/20 0.40
TUBB8 Q3ZCM7 1/20 0.40
TUBA3E Q6PEY2 1/20 0.40
TUBA1A Q71U36 1/20 0.40
TUBA1C Q9BQE3 1/20 0.40
TUBB6 Q9BUF5 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9641851 0.98 ABCB11 (0.97) ABCB11MAPTHTTKDM4ETP53
SCHEMBL9642681 0.98 ABCB11 (0.97) ABCB11MAPTHTTKDM4ETP53
SCHEMBL9641850 0.91 ABCB11 (0.83) ABCB11MAPTHTTKDM4ETP53
SCHEMBL9627469 0.91 ABCB11 (0.83) ABCB11MAPTHTTKDM4ETP53
SCHEMBL9629374 0.91 ABCB11 (0.83) ABCB11MAPTHTTKDM4ETP53
SCHEMBL9642000 0.91 ABCB11 (0.83) ABCB11MAPTHTTKDM4ETP53
SCHEMBL9643348 0.90 ABCB11 (0.81) ABCB11MAPTHTTKDM4ETP53
SCHEMBL10781871 0.90 ABCB11 (0.81) ABCB11MAPTHTTKDM4ETP53
SCHEMBL9643774 0.90 ABCB11 (0.81) ABCB11MAPTHTTKDM4ETP53
SCHEMBL9641979 0.90 ABCB11 (0.81) ABCB11MAPTHTTKDM4ETP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 719 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250332143-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA PLUTO INC (KR) 2025-10-30 US claimed
EP-4494639-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA Pluto Inc. (KR) 2025-01-22 EP claimed
WO-2023177128-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA 주식회사 플루토 2023-09-21 WO claimed
US-20150320697-A1 Methods For Bone Treatment By Modulating An Arachidonic Acid Metabolic or Signaling Pathway ACCELALOX, INC. 2015-11-12 US claimed
EP-1947942-B1 METHODS FOR BONE TREATMENT BY MODULATING AN ARACHIDONIC ACID METABOLIC OR SIGNALING PATHWAY ACCELALOX INC (US) 2015-07-29 EP claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-8980851-B2 Methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway ACCELALOX, INC. (US) 2015-03-17 US claimed
WO-2014031586-A2 METHODS FOR TREATING CARDIOVASCULAR DISEASES TALLIKUT PHARMACEUTICALS, INC. (US) 2014-02-27 WO claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
CN-1268887-A Novel compounds for the treatment of psoriasis GIORGIO ENDRICI (IT) 2000-10-04 CN claimed
EP-0888127-A1 COMBINATIONS HAVING IMMUNOSUPPRESSIVE EFFECTS, CONTAINING CYCLOOXYGENASE-2-INHIBITORS AND 5-LIPOXYGENASE INHIBITORS G.D. SEARLE & CO. (US) 1999-01-07 EP claimed
EP-0833622-A1 COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR G.D. SEARLE & CO. (US) 1998-04-08 EP claimed
EP-0800815-A2 Use of at least one lypoxygenase inhibitor and at least one cyclo-oxygenase inhibitor to alter hair growth L'OREAL (FR) 1997-10-15 EP claimed
WO-1997029776-A1 COMBINATIONS HAVING IMMUNOSUPPRESSIVE EFFECTS, CONTAINING CYCLOOXYGENASE-2-INHIBITORS AND 5-LIPOXYGENASE INHIBITORS G.D. SEARLE & CO. (US) 1997-08-21 WO claimed
WO-1996041626-A1 COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR G.D. SEARLE & CO. (US) 1996-12-27 WO claimed
EP-0648488-A1 Method to alter hairgrowth and compositions therefor L'OREAL (FR) 1995-04-19 EP claimed
US-4933489-A Process for the manufacture of 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene WARNER-LAMBERT COMPANY (US) 1990-06-12 US claimed
EP-0221474-B1 PROCESS FOR THE MANUFACTURE OF 6-CHLORO-1,4-DIACETOXY-2,3-DIMETHOXYNAPHTHALENE WARNER-LAMBERT COMPANY (US) 1990-01-17 EP claimed
EP-0221474-A1 Process for the manufacture of 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene WARNER-LAMBERT COMPANY (US) 1987-05-13 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250332143-A1 COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA MYOF, ALOX5, MYLK2 ABCB11 4875/4885MAPT 3742/4885HTT 2822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.