Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.42 |
| ▸ | TUBB | P07437 | 6/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627435 | 0.87 | HTT (0.47) | HTTKDM4EGAAMAPTABCB11 | |
| SCHEMBL9628174 | 0.84 | HTT (0.50) | HTTKDM4ETP53GAAMAPT | |
| SCHEMBL9627544 | 0.83 | HTT (0.46) | HTTKDM4ETP53GAAMAPT | |
| SCHEMBL9627553 | 0.83 | ABCB11 (0.67) | HTTKDM4ETP53GAAMAPT | |
| SCHEMBL9628320 | 0.82 | MAPT (0.67) | HTTKDM4ETP53GAAMAPT | |
| SCHEMBL9628179 | 0.81 | HTT (0.43) | HTTKDM4ETP53GAAMAPT | |
| SCHEMBL9642607 | 0.80 | ABCB11 (0.67) | HTTKDM4ETP53GAAMAPT | |
| SCHEMBL9627441 | 0.80 | BACE1 (0.49) | HTTKDM4ETP53GAAMAPT | |
| SCHEMBL9627649 | 0.79 | HTT (0.50) | HTTKDM4ETP53GAAMAPT | |
| SCHEMBL9642593 | 0.78 | ABCB11 (0.56) | HTTKDM4ETP53GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |