Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627754 | 0.96 | TOP2A (0.48) | TOP2AEPHX2MEN1KMT2AKDM4E | |
| SCHEMBL9629315 | 0.91 | TOP2A (0.48) | TOP2AEPHX2MEN1KMT2AKDM4E | |
| SCHEMBL9627943 | 0.90 | TRPV1 (0.47) | TOP2AMEN1KMT2AALOX15TRPV1 | |
| SCHEMBL9627564 | 0.87 | ALOX15 (0.43) | TOP2AMEN1KMT2AKDM4ERECQL | |
| SCHEMBL9628751 | 0.84 | MEN1 (0.42) | MEN1KMT2AKDM4EALOX15ALDH1A1 | |
| SCHEMBL9627415 | 0.84 | TOP2A (0.49) | TOP2AMEN1KMT2AKDM4ERECQL | |
| SCHEMBL29368692 | 0.84 | KMT2A (0.51) | EPHX2MEN1KMT2AKDM4ERECQL | |
| SCHEMBL20398450 | 0.84 | KMT2A (0.51) | EPHX2MEN1KMT2AKDM4ERECQL | |
| SCHEMBL21396955 | 0.83 | EPHX2 (0.47) | TOP2AEPHX2MEN1KMT2AKDM4E | |
| SCHEMBL9628129 | 0.83 | TOP2A (0.48) | TOP2AMEN1KMT2AKDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |