Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.44 |
| ▸ | POLM | Q9NP87 | 1/20 | 0.43 |
| ▸ | POLK | Q9UBT6 | 1/20 | 0.43 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.43 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627982 | 0.92 | ALOX5 (0.43) | KDM4EMEN1RECQLKMT2AALOX15 | |
| SCHEMBL9628078 | 0.88 | TOP2A (0.49) | TOP2AKDM4EMEN1RECQLKMT2A | |
| SCHEMBL9627754 | 0.87 | TOP2A (0.48) | TOP2AKDM4EMEN1RECQLKMT2A | |
| SCHEMBL9629315 | 0.87 | TOP2A (0.48) | TOP2AKDM4EMEN1RECQLKMT2A | |
| SCHEMBL9627534 | 0.85 | L3MBTL1 (0.43) | MEN1KMT2AALOX15ALDH1A1CYP1A2 | |
| SCHEMBL9628328 | 0.83 | TOP2A (0.46) | TOP2AKDM4EMEN1RECQLKMT2A | |
| SCHEMBL23271906 | 0.81 | KDM4E (0.58) | TOP2AKDM4EMEN1RECQLKMT2A | |
| SCHEMBL30003358 | 0.81 | KDM4E (0.58) | TOP2AKDM4EMEN1RECQLKMT2A | |
| SCHEMBL23271970 | 0.80 | KDM4E (0.56) | TOP2AKDM4EMEN1RECQLKMT2A | |
| SCHEMBL23271803 | 0.80 | KDM4E (0.56) | TOP2AKDM4EMEN1RECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |