Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 4/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL516450 | 0.96 | SLC22A1 (0.47) | SLC22A1DNM1CYP2D6CYP2C19SLC22A2 | |
| Hydrochloric Acid SCHEMBL27702766 | 0.86 | SLC22A1 (0.39) | SLC22A1 | |
| SCHEMBL27898011 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL4850830 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL9629148 | 0.74 | SLC22A1 (0.58) | SLC22A1DNM1SLC22A2 | |
| SCHEMBL232230 | 0.72 | — | — | |
| SCHEMBL8152125 | 0.72 | SLC22A1 (0.59) | SLC22A1DNM1SLC22A2 | |
| Hydrochloric Acid SCHEMBL1194919 | 0.72 | — | — | |
| Water SCHEMBL7200803 | 0.72 | SLC22A1 (0.50) | SLC22A1DNM1SLC22A2 | |
| SCHEMBL10863762 | 0.69 | SLC22A1 (0.61) | SLC22A1DNM1SLC22A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0027645-B1 | PROCESS FOR PREPARING HYDRAZINES | Osborg, Hans (US) | 1983-01-12 | — | — | EP | claimed |
| US-4286108-A | Process for preparing hydrazines | BURKE & BURKE | 1981-08-25 | — | — | US | claimed |
| EP-0027645-A1 | Process for preparing hydrazines | Osborg, Hans (US) | 1981-04-29 | — | — | EP | claimed |
| EP-0134259-B1 | IMPROVED PROCESS FOR PREPARING HYDRAZINES | Osborg, Hans (US) | 1992-05-27 | — | — | EP | disclosed |
| US-4789539-A | REACTING ALKALI OR ALKALINE EARTH METAL AMIDE WITH CHLORINE | OSBORG HANS (US) | 1988-12-06 | — | — | US | disclosed |
| US-4695292-A | AROMATIC HYDRAZINE DERIVATIVES | OSBORG HANS (US) | 1987-09-22 | — | — | US | disclosed |
| US-4677227-A | HYDROCARBYLCHLORAMINE, CHLORINE MONOXIDE | Osborg, Hans (US) | 1987-06-30 | — | — | US | disclosed |
| US-4508695-A | Process for preparing hydrazines | OSBORG HANS | 1985-04-02 | — | — | US | disclosed |
| EP-0134259-A1 | Improved process for preparing hydrazines | Osborg, Hans (US) | 1985-03-20 | — | — | EP | disclosed |
| EP-0027645-B1 | PROCESS FOR PREPARING HYDRAZINES | Osborg, Hans (US) | 1983-01-12 | — | — | EP | disclosed |
| US-4286108-A | Process for preparing hydrazines | BURKE & BURKE | 1981-08-25 | — | — | US | disclosed |
| EP-0027645-A1 | Process for preparing hydrazines | Osborg, Hans (US) | 1981-04-29 | — | — | EP | disclosed |