Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 2/20 | 0.58 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10863762 | 0.97 | SLC22A1 (0.61) | SLC22A1DNM1ALDH1A1TP53CYP3A4 | |
| SCHEMBL8152125 | 0.94 | SLC22A1 (0.59) | SLC22A1DNM1ALDH1A1TP53CYP3A4 | |
| Water SCHEMBL7200803 | 0.81 | SLC22A1 (0.50) | SLC22A1DNM1ALDH1A1TP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL29019046 | 0.80 | DNM1 (0.62) | SLC22A1DNM1ALDH1A1TP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL11123479 | 0.80 | DNM1 (0.62) | SLC22A1DNM1ALDH1A1TP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL8030104 | 0.80 | DNM1 (0.62) | SLC22A1DNM1ALDH1A1TP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL29062421 | 0.80 | DNM1 (0.62) | SLC22A1DNM1ALDH1A1TP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL11124862 | 0.80 | DNM1 (0.62) | SLC22A1DNM1ALDH1A1TP53CYP3A4 | |
| SCHEMBL8419983 | 0.79 | SLC22A1 (0.61) | SLC22A1DNM1ALDH1A1TP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL23501564 | 0.78 | SLC22A1 (0.93) | SLC22A1DNM1ALDH1A1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0134259-B1 | IMPROVED PROCESS FOR PREPARING HYDRAZINES | Osborg, Hans (US) | 1992-05-27 | — | — | EP | disclosed |
| US-4789539-A | REACTING ALKALI OR ALKALINE EARTH METAL AMIDE WITH CHLORINE | OSBORG HANS (US) | 1988-12-06 | — | — | US | disclosed |
| US-4677227-A | HYDROCARBYLCHLORAMINE, CHLORINE MONOXIDE | Osborg, Hans (US) | 1987-06-30 | — | — | US | disclosed |
| US-4508695-A | Process for preparing hydrazines | OSBORG HANS | 1985-04-02 | — | — | US | disclosed |
| EP-0134259-A1 | Improved process for preparing hydrazines | Osborg, Hans (US) | 1985-03-20 | — | — | EP | disclosed |
| US-4286108-A | Process for preparing hydrazines | BURKE & BURKE | 1981-08-25 | — | — | US | disclosed |