Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 1.00 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3138593 | 0.84 | ALOX5 (0.80) | ALOX5TRPM8ALDH1A1MEN1KMT2A | |
| SCHEMBL9629498 | 0.83 | ALOX5 (0.71) | ALOX5CDC7DBF4 | |
| SCHEMBL11466268 | 0.82 | ALOX5 (0.69) | ALOX5RAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL9630496 | 0.79 | ALOX5 (0.65) | ALOX5TRPM8RAB9ANPC1KDM4E | |
| SCHEMBL9628733 | 0.75 | ALOX5 (1.00) | ALOX5TRPM8 | |
| SCHEMBL11904930 | 0.75 | ALOX5 (0.71) | ALOX5TRPM8KDM4EALDH1A1CYP1A2 | |
| SCHEMBL9628717 | 0.75 | ALOX5 (1.00) | ALOX5TRPM8CDC7DBF4MEN1 | |
| SCHEMBL1459975 | 0.75 | ALOX5 (0.60) | ALOX5TRPM8RAB9ANPC1KDM4E | |
| SCHEMBL1458929 | 0.75 | ALOX5 (0.60) | ALOX5TRPM8RAB9ANPC1KDM4E | |
| SCHEMBL12335580 | 0.75 | ALOX5 (0.59) | ALOX5TRPM8RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124342-A | Antiinflammatory, antiarthritic agents; antiallergens; skin disorders | ABBOTT LABORATORIES (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0457803-A4 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | — | 1991-12-04 | — | — | EP | disclosed |
| EP-0457803-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-11-27 | — | — | EP | disclosed |
| WO-1990009801-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-09-07 | — | — | WO | disclosed |
| WO-1990009381-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-08-23 | — | — | WO | disclosed |