Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.62 |
| ▸ | RARG | P13631 | 3/20 | 0.62 |
| ▸ | RARA | P10276 | 2/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3798800 | 0.87 | ALOX5 (0.56) | RARBRARGRARAALOX5MEN1 | |
| SCHEMBL7823497 | 0.87 | ALOX5 (0.73) | RARBRARGRARAALOX5MEN1 | |
| SCHEMBL9628036 | 0.86 | KMT2A (0.67) | RARBRARGRARAALOX5MEN1 | |
| SCHEMBL9630614 | 0.79 | KDM4E (0.72) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL4190297 | 0.76 | RARB (0.83) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL4190212 | 0.76 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL4597544 | 0.76 | RARB (0.98) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL9555334 | 0.74 | ALOX5 (0.52) | RARBRARGRARAALOX5MEN1 | |
| SCHEMBL4188775 | 0.74 | RARB (1.00) | RARBRARGRARAHRH3 | |
| SCHEMBL15349239 | 0.74 | RARB (0.61) | RARBRARGRARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124342-A | Antiinflammatory, antiarthritic agents; antiallergens; skin disorders | ABBOTT LABORATORIES (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0457803-A4 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | — | 1991-12-04 | — | — | EP | disclosed |
| EP-0457803-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-11-27 | — | — | EP | disclosed |
| WO-1990009801-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-09-07 | — | — | WO | disclosed |
| WO-1990009381-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-08-23 | — | — | WO | disclosed |