SCHEMBL9628849

SCHEMBL9628849

Fc1c(Cl)cc(Cl)c(F)c1C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 2/20 0.38
CYP3A4 P08684 1/20 0.32
MAPK1 P28482 1/20 0.30
AHR P35869 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetonitrile SCHEMBL22660868 0.87 NOTUM (0.35) NOTUM
SCHEMBL24610557 0.76 POLB (0.31) CYP3A4
SCHEMBL7272272 0.74 MEN1 (0.34)
SCHEMBL668872 0.72 PDE2A (0.41) CYP3A4
SCHEMBL9693627 0.72 NOTUM (0.43) NOTUM
SCHEMBL8528070 0.72 CYP3A4 (0.41) CYP3A4MAPK1AHR
SCHEMBL312355 0.71 SMN1; SMN2 (0.42)
SCHEMBL1998599 0.71 SMN1; SMN2 (0.37)
SCHEMBL1322693 0.71 NOTUM (0.36) NOTUM
SCHEMBL17164553 0.71 SMN1; SMN2 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0270964-B1 PROCESS FOR OBTAINING SUBSTITUTED FLUOROBENZENES BAYER AG (DE) 1992-07-08 EP disclosed
EP-0302326-B1 PROCESS FOR PREPARING FLUORINATED AND OPTIONALLY ALSO CHLORINATED BENZOTRIFLUORIDES, AND BENZOTRIFLUORIDES BAYER AG (DE) 1992-04-15 EP disclosed
US-4962246-A INSECTICIDE INTERMEDIATES BAYER AKTIENGESELLSCHAFT (DE) 1990-10-09 US disclosed
US-4885415-A HYDROGENATION, DECHLORINATION, CATALYSIS BAYER AKTIENGESELLSCHAFT (DE) 1989-12-05 US disclosed
US-4868347-A SOLVENT EXTRACTION BAYER AKTIENGESELLSCHAFT (DE) 1989-09-19 US disclosed
EP-0302326-A1 Process for preparing fluorinated and optionally also chlorinated benzotrifluorides, and benzotrifluorides BAYER AG (DE) 1989-02-08 EP disclosed