Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 8/20 | 0.97 |
| ▸ | CDC7 | O00311 | 4/20 | 0.70 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15048954 | 0.98 | TRPM8 (1.00) | TRPM8CDC7DBF4ALDH1A1HPGD | |
| SCHEMBL8339659 | 0.83 | TRPM8 (0.73) | TRPM8CDC7DBF4ALDH1A1HPGD | |
| SCHEMBL974923 | 0.83 | TRPM8 (0.73) | TRPM8CDC7DBF4ALDH1A1HPGD | |
| SCHEMBL6338322 | 0.82 | TRPM8 (1.00) | TRPM8CDC7DBF4MAPTKDM4E | |
| SCHEMBL1726531 | 0.82 | TRPM8 (0.71) | TRPM8CDC7DBF4ALDH1A1HPGD | |
| SCHEMBL13674669 | 0.82 | TRPM8 (0.71) | TRPM8CDC7DBF4ALDH1A1HPGD | |
| SCHEMBL15048961 | 0.80 | CDC7 (0.73) | TRPM8CDC7DBF4ALDH1A1HPGD | |
| SCHEMBL6336484 | 0.78 | TRPM8 (0.66) | TRPM8CDC7DBF4ALDH1A1HPGD | |
| SCHEMBL2076554 | 0.77 | TRPM8 (0.64) | TRPM8CDC7DBF4ALDH1A1HPGD | |
| SCHEMBL24131828 | 0.74 | TRPM8 (0.60) | TRPM8CDC7DBF4ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124342-A | Antiinflammatory, antiarthritic agents; antiallergens; skin disorders | ABBOTT LABORATORIES (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0457803-A4 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | — | 1991-12-04 | — | — | EP | disclosed |
| EP-0457803-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-11-27 | — | — | EP | disclosed |
| WO-1990009801-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-09-07 | — | — | WO | disclosed |
| WO-1990009381-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-08-23 | — | — | WO | disclosed |