Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | SSTR5 | P35346 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9697200 | 0.96 | KCNH2 (0.62) | KCNH2NR4A2TSHRNPC1RAB9A | |
| Fumaric Acid SCHEMBL9631572 | 0.92 | KCNH2 (0.51) | KCNH2NR4A2TSHRNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL9631713 | 0.89 | KCNH2 (0.54) | KCNH2NR4A2TSHRNPC1RAB9A | |
| SCHEMBL9630126 | 0.88 | KCNH2 (0.44) | KCNH2NR4A2TSHRNPC1RAB9A | |
| SCHEMBL14198334 | 0.84 | TSHR (0.52) | KCNH2NR4A2TSHRNPC1RAB9A | |
| SCHEMBL6996422 | 0.84 | KCNH2 (0.62) | KCNH2NR4A2SOS1SSTR5HTT | |
| SCHEMBL10397086 | 0.83 | KCNH2 (0.47) | KCNH2NR4A2TSHRNPC1RAB9A | |
| Water SCHEMBL9876754 | 0.82 | KCNH2 (0.46) | KCNH2NR4A2TSHRNPC1RAB9A | |
| Water SCHEMBL9876758 | 0.82 | KCNH2 (0.46) | KCNH2NR4A2TSHRNPC1RAB9A | |
| SCHEMBL9303969 | 0.82 | KCNH2 (0.60) | KCNH2NR4A2SOS1SSTR5HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |
| EP-0297661-A1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-04 | — | — | EP | disclosed |