Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.62 |
| ▸ | SSTR5 | P35346 | 7/20 | 0.45 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HLA-A | P04439 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9697200 | 0.87 | KCNH2 (0.62) | KCNH2NR4A2SSTR5SOS1LMNA | |
| Hydrochloric Acid SCHEMBL9302235 | 0.85 | KCNH2 (0.57) | KCNH2NR4A2SSTR5SOS1LMNA | |
| Hydrochloric Acid SCHEMBL8567744 | 0.85 | KCNH2 (0.57) | KCNH2NR4A2SSTR5SOS1LMNA | |
| SCHEMBL9629478 | 0.84 | KCNH2 (0.58) | KCNH2NR4A2SSTR5SOS1LMNA | |
| SCHEMBL9594585 | 0.83 | LMNA (0.50) | KCNH2NR4A2SSTR5LMNAGAA | |
| SCHEMBL9385557 | 0.83 | KCNH2 (0.52) | KCNH2NR4A2SSTR5LMNAGAA | |
| SCHEMBL9387373 | 0.83 | SSTR5 (0.46) | KCNH2NR4A2SSTR5LMNAGAA | |
| SCHEMBL7500613 | 0.83 | KCNH2 (0.65) | KCNH2NR4A2SSTR5LMNAALDH1A1 | |
| SCHEMBL9382529 | 0.82 | KCNH2 (0.53) | KCNH2NR4A2SSTR5LMNAGAA | |
| SCHEMBL7984722 | 0.81 | KCNH2 (0.60) | KCNH2NR4A2SSTR5SOS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920425-B1 | SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | AVENTIS PHARMA INC (US) | 2003-02-19 | — | — | EP | disclosed |
| EP-0888336-B1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)P IPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | AVENTIS PHARMA INC (US) | 2002-08-07 | — | — | EP | disclosed |
| US-6211199-B1 | HISTAMINE AND TACHYKININ RECEPTOR ANTAGONISTS; ANTIASTHMATICS, ANTIEMETICS; RESPIRATORY SYSTEM DISORDERS, INFLAMMATORY BOWEL DISEASE, CONJUNCTIVITIS | AVENTIS PHARMACEUTICALS INC. | 2001-04-03 | — | — | US | disclosed |
| US-5922737-A | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-13 | — | — | US | disclosed |
| EP-0393738-B1 | Hydroxyalkylfuranyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1994-11-30 | — | — | EP | disclosed |
| US-5272150-A | Hydroxyalkylfuranyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-12-21 | — | — | US | disclosed |
| EP-0393738-A1 | Hydroxyalkylfuranyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-10-24 | — | — | EP | disclosed |