Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 7/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128946 | 0.87 | HTR1A (0.47) | HTR1AHTR2CKDM4EMEN1CYP3A4 | |
| SCHEMBL9629785 | 0.85 | ADRA2A (0.44) | HTR1AHTR2CKDM4EMEN1CYP3A4 | |
| Barmastine SCHEMBL30712053 | 0.82 | KDM4E (0.45) | HTR1AHTR2CKDM4EMEN1CYP3A4 | |
| Barmastine SCHEMBL141926 | 0.82 | KDM4E (0.45) | HTR1AHTR2CKDM4EMEN1CYP3A4 | |
| Hydrochloric Acid SCHEMBL9800689 | 0.82 | HTR1A (0.54) | HTR1AHTR2CKDM4EMEN1CYP3A4 | |
| SCHEMBL9535189 | 0.80 | HTR1A (0.46) | HTR1AHTR2CKDM4EMEN1CYP3A4 | |
| SCHEMBL9630461 | 0.80 | HTR1A (0.40) | HTR1AHTR2CMEN1CYP3A4CYP2D6 | |
| SCHEMBL9689852 | 0.80 | HTR1A (0.46) | HTR1AHTR2CKDM4EMEN1CYP3A4 | |
| SCHEMBL9629392 | 0.79 | TP53 (0.40) | HTR1AMAPTHPGDEEDSCN9A | |
| SCHEMBL9629371 | 0.78 | HTR1A (0.42) | HTR1AHTR2CMEN1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | claimed |