Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 17/20 | 0.65 |
| ▸ | CA2 | P00918 | 17/20 | 0.65 |
| ▸ | CA7 | P43166 | 12/20 | 0.65 |
| ▸ | CA13 | Q8N1Q1 | 12/20 | 0.65 |
| ▸ | CA12 | O43570 | 5/20 | 0.65 |
| ▸ | CA9 | Q16790 | 5/20 | 0.65 |
| ▸ | CA3 | P07451 | 4/20 | 0.65 |
| ▸ | CA4 | P22748 | 4/20 | 0.65 |
| ▸ | CA6 | P23280 | 4/20 | 0.65 |
| ▸ | CA5A | P35218 | 4/20 | 0.65 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.65 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630166 | 0.88 | CA1 (0.50) | CA1CA2CA7CA13CA12 | |
| SCHEMBL9630937 | 0.86 | CA1 (0.48) | CA1CA2CA7CA13CA12 | |
| SCHEMBL9630165 | 0.84 | CA1 (0.47) | CA1CA2CA7CA13CA12 | |
| SCHEMBL8422346 | 0.83 | KDM4E (0.53) | CA1CA2CA7CA13CA12 | |
| SCHEMBL10383655 | 0.83 | CA1 (0.46) | CA1CA2CA7CA13CA12 | |
| Water SCHEMBL10383299 | 0.82 | CA1 (0.45) | CA1CA2CA7CA13CA12 | |
| SCHEMBL18426397 | 0.79 | CA1 (1.00) | CA1CA2CA7CA13CA12 | |
| SCHEMBL9630198 | 0.78 | CA1 (0.73) | CA1CA2CA7CA13CA12 | |
| SCHEMBL9632120 | 0.76 | KDM4E (0.48) | CA1CA2CA7CA13CA12 | |
| SCHEMBL10382771 | 0.75 | CA1 (0.44) | CA1CA2CA7CA13CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0324988-B1 | 4-CHLOR-3-SULFAMOYL BENZOIC ACID HYDRAZIDES, PROCESS FOR THEIR PREPARATION, MEDICINES CONTAINING THEM AND USE OF THESE COMPOUNDS IN THE PREPARATION OF DIURETIC AND SALT REDUCING ACTIVITY MEDICINES | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1992-04-29 | — | — | EP | disclosed |
| US-4916149-A | Diuretic and saluretic 4-chloro-3-sulfamoylbenzoic acid hydrazides | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1990-04-10 | — | — | US | disclosed |
| EP-0324988-A1 | 4-Chlor-3-sulfamoyl benzoic acid hydrazides, process for their preparation, medicines containing them and use of these compounds in the preparation of diuretic and salt reducing activity medicines | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1989-07-26 | — | — | EP | disclosed |