SCHEMBL9630669

SCHEMBL9630669

O=C1c2ccc(O)cc2C(=O)N1c1ccc(Cc2ccc(N3C(=O)c4ccc(O)cc4C3=O)cc2)cc1

nearest known ligand 0.77

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 11/20 0.77
ESR2 Q92731 8/20 0.77
STAT3 P40763 1/20 0.61
NPSR1 Q6W5P4 1/20 0.61
NR1H3 Q13133 3/20 0.59
APAF1 O14727 1/20 0.56
POLB P06746 1/20 0.56
BRD4 O60885 1/20 0.52
ANPEP P15144 2/20 0.51
DPP4 P27487 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9632877 0.89 ESR1 (0.96) ESR1ESR2NR1H3APAF1POLB
SCHEMBL5530724 0.88 ESR1 (1.00) ESR1ESR2NR1H3APAF1POLB
SCHEMBL15858818 0.85 NR1H3 (0.81) ESR1ESR2STAT3NPSR1NR1H3
SCHEMBL13899540 0.83 ESR1 (0.83) ESR1ESR2APAF1POLBBRD4
SCHEMBL4258975 0.81 ESR1 (0.80) ESR1ESR2NPSR1NR1H3APAF1
SCHEMBL8615277 0.81 ESR1 (1.00) ESR1ESR2NR1H3APAF1POLB
SCHEMBL4260868 0.81 ESR1 (0.73) ESR1ESR2NPSR1APAF1POLB
SCHEMBL9468751 0.80 CASP1 (0.71) ESR1ESR2STAT3NPSR1NR1H3
SCHEMBL9631792 0.80 ESR1 (0.77) ESR1ESR2NPSR1APAF1POLB
SCHEMBL9564296 0.80 CA9 (0.66) NPSR1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-63122668-A None JP disclosed
EP-0195402-B1 BIS(HYDROXYPHTHALIMIDE) AND PROCESS FOR PREPARING THE SAME, AND PROCESS FOR PREPARING POLYESTERIMIDE BY THE USE THEREOF NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) 1992-06-10 EP disclosed
US-4948831-A MOLDING HEAT RESISTANT MIXTURES NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) 1990-08-14 US disclosed
US-4855390-A Process for preparing polyesterimide from bis(hydroxyphthalimide) NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) 1989-08-08 US disclosed
US-4808676-A HEAT RESISTANCE, WATERPROOF FILM NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) 1989-02-28 US disclosed
US-4769475-A Bis(hydroxyphthalimide) and process for preparing the same, and process for preparing polyesterimide by the use thereof NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) 1988-09-06 US disclosed
JP-S63122668-A PRODUCTION OF BIS(HYDROXYPHTHALIMIDE) NIPPON TELEGR & TELEPH CORP <NTT> 1988-05-26 JP disclosed
EP-0195402-A2 Bis(hydroxyphthalimide) and process for preparing the same, and process for preparing polyesterimide by the use thereof NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) 1986-09-24 EP disclosed