Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9631025 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2PDE4BPDE3BPDE3AMAPT | |
| SCHEMBL11657483 | 0.74 | SMN1; SMN2 (0.59) | SMN1; SMN2PDE4BPDE5APDE3BPDE3A | |
| SCHEMBL11627707 | 0.71 | SMN1; SMN2 (0.59) | SMN1; SMN2PDE4BPDE5APDE3BPDE3A | |
| SCHEMBL11626246 | 0.71 | SMN1; SMN2 (0.59) | SMN1; SMN2PDE4BPDE5APDE3BPDE3A | |
| SCHEMBL9686080 | 0.70 | SMN1; SMN2 (0.49) | SMN1; SMN2PDE4BPDE5APDE3BPDE3A | |
| SCHEMBL11637547 | 0.69 | SMN1; SMN2 (0.51) | SMN1; SMN2PDE4BPDE5APDE3BPDE3A | |
| SCHEMBL11880474 | 0.68 | SMN1; SMN2 (0.54) | SMN1; SMN2PDE4BPDE5APDE3BPDE3A | |
| SCHEMBL7298081 | 0.68 | SMN1; SMN2 (0.50) | SMN1; SMN2PDE4BPDE5APDE3BPDE3A | |
| SCHEMBL31542047 | 0.68 | SMN1; SMN2 (0.54) | SMN1; SMN2PDE4BPDE5APDE3BPDE3A | |
| SCHEMBL11702077 | 0.68 | SMN1; SMN2 (0.54) | SMN1; SMN2PDE4BPDE5APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153210-A | Hypoglycemic agent, animal growth regulator; veterinary medicine | BEECHAM GROUP P.L.C. (GB) | 1992-10-06 | — | — | US | disclosed |
| EP-0236624-A2 | Substituted phenyl ethanol amines, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-09-16 | — | — | EP | disclosed |