Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630710 | 0.83 | SIGMAR1 (0.45) | CYP2D6MEN1KMT2ALMNAKDM4E | |
| SCHEMBL10525157 | 0.77 | CYP2D6 (0.56) | CYP2D6MEN1KMT2ALMNASLC18A3 | |
| SCHEMBL248803 | 0.76 | TDP1 (0.51) | SLC18A3SIGMAR1 | |
| SCHEMBL9631240 | 0.74 | CYP2D6 (0.44) | CYP2D6MEN1KMT2ALMNASLC18A3 | |
| Sparteine SCHEMBL18468288 | 0.72 | CYP2D6 (1.00) | CYP2D6MEN1KMT2ALMNASLC18A3 | |
| Sparteine SCHEMBL12301225 | 0.72 | CYP2D6 (1.00) | CYP2D6MEN1KMT2ALMNASLC18A3 | |
| Sparteine SCHEMBL1753344 | 0.72 | CYP2D6 (1.00) | CYP2D6MEN1KMT2ALMNASLC18A3 | |
| Sparteine SCHEMBL14331495 | 0.72 | CYP2D6 (1.00) | CYP2D6MEN1KMT2ALMNASLC18A3 | |
| Sparteine SCHEMBL22619501 | 0.72 | CYP2D6 (1.00) | CYP2D6MEN1KMT2ALMNASLC18A3 | |
| Sparteine SCHEMBL14029290 | 0.72 | CYP2D6 (1.00) | CYP2D6MEN1KMT2ALMNASLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273272-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 17-BENZYL SPARTEINE DERIVATIVES WITH A POSITIVE INOTROPIC EFFECT | Kali-Chemie Pharma GmbH (DE) | 1992-05-06 | — | — | EP | claimed |
| EP-0206155-B1 | AROMATIC COMPOUNDS, THEIR PREPARATION AND USE | Kali-Chemie Pharma GmbH (DE) | 1989-10-18 | — | — | EP | claimed |
| EP-0273272-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 17-BENZYL SPARTEINE DERIVATIVES WITH A POSITIVE INOTROPIC EFFECT | Kali-Chemie Pharma GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |
| EP-0273272-A2 | Pharmaceutical compositions containing 17-benzyl sparteine derivatives with a positive inotropic effect | Kali-Chemie Pharma GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |