Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | EED | O75530 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9631247 | 0.83 | CYP2D6 (0.51) | SIGMAR1CYP2D6MEN1KMT2ALMNA | |
| SCHEMBL9630704 | 0.79 | SIGMAR1 (0.45) | SIGMAR1EEDHRH3MEN1KMT2A | |
| SCHEMBL3159840 | 0.69 | ALDH1A1 (0.54) | EEDHRH3LMNAALDH1A1HTR1A | |
| SCHEMBL27792902 | 0.69 | ALDH1A1 (0.54) | SIGMAR1EEDHRH3LMNAALDH1A1 | |
| SCHEMBL27617429 | 0.69 | ALDH1A1 (0.54) | SIGMAR1EEDHRH3LMNAALDH1A1 | |
| SCHEMBL27617425 | 0.68 | ALDH1A1 (0.52) | SIGMAR1EEDHRH3MEN1KMT2A | |
| SCHEMBL11480261 | 0.67 | CHRNB4 (0.59) | SIGMAR1EEDHRH3ALDH1A1HTR1A | |
| SCHEMBL27617581 | 0.67 | ALDH1A1 (0.55) | EEDHRH3LMNAALDH1A1HTR1A | |
| SCHEMBL25698257 | 0.67 | EED (0.71) | SIGMAR1EEDHRH3LMNAALDH1A1 | |
| SCHEMBL7896137 | 0.67 | EED (0.52) | SIGMAR1EEDHRH3LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273272-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 17-BENZYL SPARTEINE DERIVATIVES WITH A POSITIVE INOTROPIC EFFECT | Kali-Chemie Pharma GmbH (DE) | 1992-05-06 | — | — | EP | claimed |