Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 2/20 | 0.56 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | KISS1R | Q969F8 | 4/20 | 0.53 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | NMUR2 | Q9GZQ4 | 3/20 | 0.52 |
| ▸ | NMUR1 | Q9HB89 | 3/20 | 0.52 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.52 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.50 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.50 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630737 | 0.96 | KISS1R (0.57) | GNRHRABCC2PTGS1KISS1REPHA2 | |
| SCHEMBL9630723 | 0.89 | NMUR2 (0.55) | GNRHRABCC2PTGS1EPHA2NMUR2 | |
| SCHEMBL9630848 | 0.87 | KISS1R (0.62) | GNRHRABCC2PTGS1KISS1RCXCL8 | |
| SCHEMBL9852696 | 0.85 | KISS1R (0.59) | KISS1R | |
| SCHEMBL29619534 | 0.85 | GNRHR (0.65) | GNRHRABCC2PTGS1KISS1RCXCR4 | |
| SCHEMBL11310188 | 0.84 | PTGS1 (0.72) | GNRHRABCC2PTGS1KISS1RNMUR2 | |
| SCHEMBL10589391 | 0.84 | EPHA2 (0.51) | EPHA2NMUR2NMUR1CXCR4 | |
| SCHEMBL9630682 | 0.84 | NMUR2 (0.57) | GNRHRPTGS1EPHA2NMUR2NMUR1 | |
| SCHEMBL30387715 | 0.83 | KISS1R (0.62) | GNRHRABCC2PTGS1KISS1RCXCR4 | |
| SCHEMBL9629930 | 0.83 | NMUR2 (0.56) | GNRHRABCC2PTGS1EPHA2NMUR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140009-A | Stable against proteolytic enzymes; anticarcinogenic agents; urogenital disorders | TAP PHARMACEUTICALS, INC. (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0480918-A1 | REDUCED SIZE LHRH ANALOGS | ABBOTT LABORATORIES (US) | 1992-04-22 | — | — | EP | disclosed |
| EP-0480918-A4 | REDUCED SIZE LHRH ANALOGS. | ABBOTT LAB (US) | 1991-06-04 | — | — | EP | disclosed |
| WO-1989007451-A1 | REDUCED SIZE LHRH ANALOGS | ABBOTT LABORATORIES (US) | 1989-08-24 | — | — | WO | disclosed |