Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.78 |
| ▸ | HTR1A | P08908 | 6/20 | 0.62 |
| ▸ | DRD2 | P14416 | 6/20 | 0.62 |
| ▸ | HTR2A | P28223 | 5/20 | 0.62 |
| ▸ | HTR7 | P34969 | 5/20 | 0.62 |
| ▸ | DRD3 | P35462 | 5/20 | 0.62 |
| ▸ | DRD4 | P21917 | 4/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.62 |
| ▸ | DRD1 | P21728 | 3/20 | 0.62 |
| ▸ | HRH1 | P35367 | 3/20 | 0.62 |
| ▸ | DRD5 | P21918 | 2/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.55 |
| ▸ | HTR1E | P28566 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9632489 | 0.96 | POLB (0.72) | POLBHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL15961309 | 0.88 | POLB (1.00) | POLBHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL15961344 | 0.84 | POLB (0.92) | POLBHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL9631368 | 0.82 | POLB (0.78) | POLBHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL4169559 | 0.81 | SIGMAR1 (0.67) | — | |
| SCHEMBL4519313 | 0.80 | KCNH2 (0.85) | POLBHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL26107525 | 0.80 | KCNH2 (0.85) | POLBHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL26108725 | 0.80 | KCNH2 (0.85) | POLBHTR1ADRD2HTR2AHTR7 | |
| Bromide SCHEMBL4174825 | 0.80 | SIGMAR1 (0.65) | — | |
| SCHEMBL1233437 | 0.79 | KCNH2 (0.69) | POLBHTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5089497-A | Dopaminergic agents | WARNER-LAMBERT COMPANY (US) | 1992-02-18 | — | — | US | claimed |
| US-5089497-A | Dopaminergic agents | WARNER-LAMBERT COMPANY (US) | 1992-02-18 | — | — | US | disclosed |