Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PTPRA | P18433 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10505998 | 0.85 | MAPT (0.47) | MAPTGAASMN1; SMN2KDM4ECYP2D6 | |
| SCHEMBL5319112 | 0.84 | SLC22A1 (0.50) | MAPTGAASMN1; SMN2KDM4ECYP2D6 | |
| SCHEMBL4881527 | 0.83 | PTPRA (0.36) | MAPTGAAPTPRASMN1; SMN2KDM4E | |
| SCHEMBL28787105 | 0.78 | MAPT (0.53) | MAPTGAASMN1; SMN2KDM4ECYP2D6 | |
| SCHEMBL29430156 | 0.78 | MAPT (0.53) | MAPTGAASMN1; SMN2KDM4ECYP2D6 | |
| SCHEMBL31650932 | 0.78 | MAPT (0.53) | MAPTGAASMN1; SMN2KDM4ECYP2D6 | |
| SCHEMBL27398624 | 0.78 | MAPT (0.53) | MAPTGAASMN1; SMN2KDM4ECYP2D6 | |
| SCHEMBL268492 | 0.78 | MAPT (0.53) | MAPTGAASMN1; SMN2KDM4ECYP2D6 | |
| SCHEMBL7288777 | 0.78 | PTPRA (0.55) | MAPTGAAPTPRASMN1; SMN2TSHR | |
| SCHEMBL6388437 | 0.78 | PTPRA (0.55) | MAPTGAAPTPRASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5079249-A | Serotine antagonists at 5-HT2 level, antiallergens, antihistamines | ADIR ET COMPAGNIE (FR) | 1992-01-07 | — | — | US | disclosed |
| US-5071847-A | BIS (ARYL) ALKENE COMPOUNDS OF HOMOPIPERIDINES USEFUL AS SEROTONIN-ANTAGONISTS | ADIR ET COMPAGNIE (FR) | 1991-12-10 | — | — | US | disclosed |
| US-5028607-A | Antiserotonine agents | ADIR ET COMPAGNIE (FR) | 1991-07-02 | — | — | US | disclosed |
| US-4943577-A | PSYCHOLOGICAL DISORDERS | ADIR ET CIE (FR) | 1990-07-24 | — | — | US | disclosed |
| US-4877788-A | ANXIOLYTIC, ANTIAGGRESSIVE OR ANTIPSYCHOTIC AGENT | ADIR ET CIE (FR) | 1989-10-31 | — | — | US | disclosed |