Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | PRCP | P42785 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9631444 | 0.84 | MAPT (0.47) | MAPTGAAKDM4EHIF1ASMN1; SMN2 | |
| SCHEMBL10505998 | 0.84 | MAPT (0.47) | PRCPMAPTGAAKDM4ESMN1; SMN2 | |
| SCHEMBL17725672 | 0.83 | ADRB2 (0.56) | GAACACNA1GADRB2KDM1AMEN1 | |
| SCHEMBL17713985 | 0.83 | ADRB2 (0.56) | GAACACNA1GADRB2KDM1AMEN1 | |
| SCHEMBL28787105 | 0.76 | MAPT (0.53) | MAPTGAAKDM4ESMN1; SMN2CYP2D6 | |
| SCHEMBL31650932 | 0.76 | MAPT (0.53) | MAPTGAAKDM4ESMN1; SMN2CYP2D6 | |
| SCHEMBL27398624 | 0.76 | MAPT (0.53) | MAPTGAAKDM4ESMN1; SMN2CYP2D6 | |
| SCHEMBL268492 | 0.76 | MAPT (0.53) | MAPTGAAKDM4ESMN1; SMN2CYP2D6 | |
| SCHEMBL29430156 | 0.76 | MAPT (0.53) | MAPTGAAKDM4ESMN1; SMN2CYP2D6 | |
| SCHEMBL3249767 | 0.76 | CYP2D6 (0.41) | MAPTGAAKDM4EHIF1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1703221-A | 2-alkyl- (2-amino-3-aryl-propionyl) -piperazine derivatives and related compounds as melanocortin receptor ligands for the treatment of obesity | PROCTER & GAMBLE (US) | 2005-11-30 | — | — | CN | claimed |
| WO-2007082666-A1 | ACYLAMINOIMIDAZOLES | BAYER HEALTHCARE AG (DE) | 2007-07-26 | — | — | WO | disclosed |
| CN-1703221-A | 2-alkyl- (2-amino-3-aryl-propionyl) -piperazine derivatives and related compounds as melanocortin receptor ligands for the treatment of obesity | PROCTER & GAMBLE (US) | 2005-11-30 | — | — | CN | disclosed |
| US-5359074-A | Process for the preparation of racemic and optically active 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and its precursors | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-25 | — | — | US | disclosed |
| US-5252738-A | Process for the preparation of racemic and optically active 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and its precursors | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-10-12 | — | — | US | disclosed |