Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633024 | 1.00 | GRIK1 (0.46) | GRIK1GRIK2HSD11B1MMP2MMP1 | |
| SCHEMBL9632094 | 0.86 | GRIK1 (0.52) | GRIK1GRIK2MMP8MMP14 | |
| SCHEMBL9632086 | 0.86 | GRIK1 (0.52) | GRIK1GRIK2MMP8MMP14 | |
| SCHEMBL9633235 | 0.86 | GRIK1 (0.52) | GRIK1GRIK2MMP8MMP14 | |
| SCHEMBL9634101 | 0.82 | GRIK1 (0.37) | GRIK1GRIK2 | |
| SCHEMBL9634107 | 0.82 | GRIK1 (0.37) | GRIK1GRIK2 | |
| SCHEMBL9633202 | 0.76 | GRIK1 (0.35) | GRIK1GRIK2 | |
| SCHEMBL9633212 | 0.76 | GRIK1 (0.35) | GRIK1GRIK2 | |
| SCHEMBL9634077 | 0.76 | HDAC3 (0.40) | GRIK1GRIK2CA12 | |
| SCHEMBL9634084 | 0.76 | HDAC3 (0.40) | GRIK1GRIK2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | claimed |
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |