Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 10/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 10/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633212 | 1.00 | GRIK1 (0.35) | GRIK1GRIK2HTR2AGRIN2DGRIN3B | |
| SCHEMBL9634101 | 0.95 | GRIK1 (0.37) | GRIK1GRIK2HTR2AGRIN2DGRIN3B | |
| SCHEMBL9634107 | 0.95 | GRIK1 (0.37) | GRIK1GRIK2HTR2AGRIN2DGRIN3B | |
| SCHEMBL9632859 | 0.83 | — | — | |
| SCHEMBL9632864 | 0.83 | — | — | |
| SCHEMBL9633235 | 0.77 | GRIK1 (0.52) | GRIK1GRIK2HTR2A | |
| SCHEMBL9632094 | 0.77 | GRIK1 (0.52) | GRIK1GRIK2HTR2A | |
| SCHEMBL9632086 | 0.77 | GRIK1 (0.52) | GRIK1GRIK2HTR2A | |
| SCHEMBL9633047 | 0.77 | FDPS (0.42) | — | |
| SCHEMBL9633024 | 0.76 | GRIK1 (0.46) | GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | claimed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | claimed |
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |