Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.52 |
| ▸ | ACP3 | P15309 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9632086 | 1.00 | GRIK1 (0.52) | GRIK1GRIK2ACP3HDAC2MMP8 | |
| SCHEMBL9632094 | 1.00 | GRIK1 (0.52) | GRIK1GRIK2ACP3HDAC2MMP8 | |
| SCHEMBL9632541 | 0.86 | FDPS (0.43) | GRIK1GRIK2ACP3MMP8MMP14 | |
| SCHEMBL9632549 | 0.86 | FDPS (0.43) | GRIK1GRIK2ACP3MMP8MMP14 | |
| SCHEMBL9633010 | 0.86 | GRIK1 (0.46) | GRIK1GRIK2MMP8MMP14 | |
| SCHEMBL9633024 | 0.86 | GRIK1 (0.46) | GRIK1GRIK2MMP8MMP14 | |
| SCHEMBL9634101 | 0.83 | GRIK1 (0.37) | GRIK1GRIK2HTR2A | |
| SCHEMBL9634107 | 0.83 | GRIK1 (0.37) | GRIK1GRIK2HTR2A | |
| SCHEMBL9634077 | 0.83 | HDAC3 (0.40) | GRIK1GRIK2HDAC2FDPSCA1 | |
| SCHEMBL9634084 | 0.83 | HDAC3 (0.40) | GRIK1GRIK2HDAC2FDPSCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | claimed |
| EP-0513587-A1 | Process for preparing 3-alkeny-lidene-1, 1-bisphosphonates | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |
| US-5103036-A | Catalyzed coupling of allyl ester with methylenebisphosphonate | E. R. SQUIBB & SONS, INC. (US) | 1992-04-07 | — | — | US | disclosed |