Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.62 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | RAD52 | P43351 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30306133 | 0.91 | HSD17B10 (0.75) | KDM4EALDH1A1HSD17B10HPGDDRD3 | |
| SCHEMBL4768364 | 0.91 | HSD17B10 (0.75) | KDM4EALDH1A1HSD17B10HPGDDRD3 | |
| SCHEMBL5753184 | 0.86 | KDM4E (0.58) | KDM4EALDH1A1HSD17B10HPGDDRD3 | |
| SCHEMBL5752800 | 0.84 | KDM4E (0.55) | KDM4EALDH1A1HSD17B10HPGDDRD3 | |
| SCHEMBL9634547 | 0.84 | KDM4E (0.79) | KDM4EALDH1A1HSD17B10HPGDDRD3 | |
| SCHEMBL9656123 | 0.83 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10HPGDDRD3 | |
| SCHEMBL21074769 | 0.81 | HSD17B10 (0.69) | KDM4EALDH1A1HSD17B10HPGDDRD3 | |
| SCHEMBL29548937 | 0.81 | HSD17B10 (0.78) | KDM4EALDH1A1HSD17B10HPGDDRD3 | |
| SCHEMBL27397656 | 0.81 | HSD17B10 (0.78) | KDM4EALDH1A1HSD17B10HPGDDRD3 | |
| SCHEMBL5328483 | 0.81 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10HPGDDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162523-A | CEPHALOSPORIN ANTIBACTERIAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 1992-11-10 | — | — | US | disclosed |
| US-5159077-A | Bactericide, antibiotic | HOFFMANN-LA ROCHE INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0409081-A1 | Beta-Lactam Derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-01-23 | — | — | EP | disclosed |