Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.79 |
| ▸ | HPGD | P15428 | 5/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
| ▸ | HTT | P42858 | 2/20 | 0.79 |
| ▸ | BRD4 | O60885 | 1/20 | 0.79 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | DRD3 | P35462 | 1/20 | 0.62 |
| ▸ | RAD52 | P43351 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13923331 | 0.92 | KDM4E (0.79) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9344503 | 0.91 | KDM4E (0.79) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL10028896 | 0.91 | KDM4E (0.84) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL27395494 | 0.89 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL3473 | 0.89 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL2221304 | 0.89 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL10913227 | 0.88 | KDM4E (0.73) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL11524201 | 0.88 | ALDH1A1 (0.98) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL10911469 | 0.88 | ALDH1A1 (0.98) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL28495826 | 0.88 | ALDH1A1 (0.98) | KDM4EALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162523-A | CEPHALOSPORIN ANTIBACTERIAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 1992-11-10 | — | — | US | disclosed |
| US-5159077-A | Bactericide, antibiotic | HOFFMANN-LA ROCHE INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0409081-A1 | Beta-Lactam Derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-01-23 | — | — | EP | disclosed |
| US-4472579-A | REACTING A PIPERAZINE WITH A CHLORO QUINOLINECARBOXYLIC ACID ESTER, HYDROLYSIS | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1984-09-18 | — | — | US | disclosed |