Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 4/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
| ▸ | EDNRB | P24530 | 1/20 | 0.30 |
| ▸ | EDNRA | P25101 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963366 | 1.00 | ENPP3 (0.37) | ENPP3ENPP1HDAC1FGFR1FGFR4 | |
| SCHEMBL967732 | 0.92 | HDAC1 (0.32) | HDAC1 | |
| SCHEMBL967733 | 0.92 | HDAC1 (0.32) | HDAC1 | |
| SCHEMBL966859 | 0.91 | PPARG (0.33) | HDAC1FGFR1FGFR4SMN1; SMN2KDM4E | |
| SCHEMBL966858 | 0.91 | PPARG (0.33) | HDAC1FGFR1FGFR4SMN1; SMN2KDM4E | |
| SCHEMBL964262 | 0.89 | ENPP3 (0.38) | ENPP3ENPP1HDAC1FGFR1FGFR4 | |
| SCHEMBL964264 | 0.89 | ENPP3 (0.38) | ENPP3ENPP1HDAC1FGFR1FGFR4 | |
| SCHEMBL968568 | 0.88 | PPARG (0.35) | HDAC1POLBALDH1A1 | |
| SCHEMBL968569 | 0.88 | PPARG (0.35) | HDAC1POLBALDH1A1 | |
| SCHEMBL967813 | 0.88 | PPARG (0.38) | ENPP3ENPP1FGFR1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009384-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2011-01-13 | — | — | US | disclosed |
| US-20080194617-A1 | Fused ring compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194617-A1 | Fused ring compound | SLC5A1, SLC5A2, GPR119 | ENPP3 1924/4885ENPP1 1528/4885HDAC1 108/4885 |
| US-20110009384-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | PPARA, PPARD, PPARG | ENPP3 2208/4885ENPP1 1752/4885HDAC1 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.