Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 15/20 | 0.75 |
| ▸ | ADRA1D | P25100 | 14/20 | 0.75 |
| ▸ | ADRA1B | P35368 | 14/20 | 0.75 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.75 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.75 |
| ▸ | HTR1A | P08908 | 2/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.75 |
| ▸ | DRD2 | P14416 | 2/20 | 0.75 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.75 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.75 |
| ▸ | HTR2A | P28223 | 2/20 | 0.75 |
| ▸ | DRD3 | P35462 | 2/20 | 0.75 |
| ▸ | HTR2B | P41595 | 2/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.75 |
| ▸ | HTR7 | P34969 | 1/20 | 0.75 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.75 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634096 | 1.00 | ADRA1A (0.75) | ADRA1AADRA1DADRA1BADRB2ADRB1 | |
| SCHEMBL9632850 | 1.00 | ADRA1A (0.75) | ADRA1AADRA1DADRA1BADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL9631950 | 0.99 | ADRA1A (0.74) | ADRA1AADRA1DADRA1BADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL9631937 | 0.99 | ADRA1A (0.74) | ADRA1AADRA1DADRA1BADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL9632447 | 0.99 | ADRA1A (0.74) | ADRA1AADRA1DADRA1BADRB2ADRB1 | |
| SCHEMBL9632049 | 0.96 | ADRA1A (0.78) | ADRA1AADRA1DADRA1BADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL9634081 | 0.95 | ADRA1A (0.77) | ADRA1AADRA1DADRA1BADRB2ADRB1 | |
| SCHEMBL9632960 | 0.94 | ADRA1D (0.85) | ADRA1AADRA1DADRA1BADRB2ADRB1 | |
| SCHEMBL9632026 | 0.94 | ADRA1D (0.76) | ADRA1AADRA1DADRA1BADRB2ADRB1 | |
| SCHEMBL9632574 | 0.94 | ADRA1A (0.79) | ADRA1AADRA1DADRA1BADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331943-B1 | PHENOXYETHYLAMINE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND COMPOSITION FOR EXHIBITING EXCELLENT ALPHA-1-BLOCKING ACTIVITY CONTAINING THE SAME | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1992-06-17 | — | — | EP | claimed |
| US-4971990-A | HYPOTENSIVE AGENTS, DYSUREA | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1990-11-20 | — | — | US | claimed |
| EP-0331943-A1 | Phenoxyethylamine derivatives, process for preparing the same, and composition for exhibiting excellent alpha-1-blocking activity containing the same | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1989-09-13 | — | — | EP | claimed |
| EP-0331943-B1 | PHENOXYETHYLAMINE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND COMPOSITION FOR EXHIBITING EXCELLENT ALPHA-1-BLOCKING ACTIVITY CONTAINING THE SAME | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1992-06-17 | — | — | EP | disclosed |
| US-4971990-A | HYPOTENSIVE AGENTS, DYSUREA | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1990-11-20 | — | — | US | disclosed |
| EP-0331943-A1 | Phenoxyethylamine derivatives, process for preparing the same, and composition for exhibiting excellent alpha-1-blocking activity containing the same | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1989-09-13 | — | — | EP | disclosed |