Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.34 |
| ▸ | VHL | P40337 | 1/20 | 0.33 |
| ▸ | ELOC | Q15369 | 1/20 | 0.33 |
| ▸ | ELOB | Q15370 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633457 | 0.83 | CYP4A11 (0.44) | TRPV1ALOX15ALDH1A1LTA4HCA2 | |
| SCHEMBL107820 | 0.83 | ESR1 (0.54) | MEN1CYP3A4KMT2AALDH1A1LTA4H | |
| SCHEMBL3079938 | 0.83 | CYP1A2 (0.46) | TRPV1ALOX15 | |
| SCHEMBL9633317 | 0.81 | ALDH1A1 (0.36) | TSHRTRPV1FNTAPGGT1BMEN1 | |
| SCHEMBL4769318 | 0.81 | TAAR1 (0.45) | TSHRTRPV1 | |
| SCHEMBL105976 | 0.80 | TRPV1 (0.51) | TRPV1ALOX15ALDH1A1 | |
| SCHEMBL3093124 | 0.78 | TAAR1 (0.52) | TSHRTRPV1CYP3A4ALOX15ALDH1A1 | |
| SCHEMBL9633219 | 0.78 | TRPV1 (0.34) | TRPV1FNTAPGGT1BCYP3A4ALOX15 | |
| SCHEMBL28503448 | 0.78 | TRPV1 (0.44) | TSHRTRPV1 | |
| SCHEMBL9637227 | 0.78 | FFAR1 (0.48) | TSHRTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |