Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | PTPRB | P23467 | 1/20 | 0.43 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | PTEN | P60484 | 1/20 | 0.43 |
| ▸ | PTPMT1 | Q8WUK0 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633729 | 1.00 | TRPV1 (0.50) | TRPV1PPARGPPARACNR2PTPRB | |
| SCHEMBL9633674 | 0.84 | KEAP1 (0.52) | PTPRBCDC25ACDC25BPTENPTPMT1 | |
| SCHEMBL9127995 | 0.83 | TRPV1 (0.51) | TRPV1KEAP1FFAR1FNTAFNTB | |
| SCHEMBL9128012 | 0.83 | TRPV1 (0.51) | TRPV1KEAP1FFAR1FNTAFNTB | |
| SCHEMBL9632012 | 0.83 | SQLE (0.43) | TRPV1PPARGPPARACNR2 | |
| SCHEMBL9631997 | 0.83 | SQLE (0.43) | TRPV1PPARGPPARACNR2 | |
| SCHEMBL9310128 | 0.82 | PPARG (0.43) | TRPV1PPARGPPARA | |
| SCHEMBL9310117 | 0.82 | PPARG (0.43) | TRPV1PPARGPPARA | |
| SCHEMBL9634087 | 0.82 | PPARG (0.41) | TRPV1PPARGPPARACNR2 | |
| SCHEMBL9634094 | 0.82 | PPARG (0.41) | TRPV1PPARGPPARACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |