Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | PTPRB | P23467 | 1/20 | 0.50 |
| ▸ | CDC25A | P30304 | 1/20 | 0.50 |
| ▸ | CDC25B | P30305 | 1/20 | 0.50 |
| ▸ | PTEN | P60484 | 1/20 | 0.50 |
| ▸ | PTPMT1 | Q8WUK0 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633735 | 0.84 | TRPV1 (0.50) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL9633729 | 0.84 | TRPV1 (0.50) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL2563669 | 0.81 | FFAR1 (0.64) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL30967790 | 0.81 | GLA (0.54) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL29237336 | 0.81 | GLA (0.54) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL29237341 | 0.81 | GLA (0.54) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL3627230 | 0.80 | KEAP1 (0.60) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL20725124 | 0.80 | KEAP1 (0.55) | KEAP1PTPRBCDC25ACDC25BPTEN | |
| SCHEMBL9633243 | 0.80 | FFAR1 (0.55) | KEAP1FFAR1ALDH1A1FFAR4 | |
| SCHEMBL70271 | 0.78 | KEAP1 (0.74) | KEAP1PTPRBCDC25ACDC25BPTEN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |