Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634053 | 1.00 | ALDH1A1 (0.46) | ALDH1A1LMNANPSR1MAPTSMN1; SMN2 | |
| SCHEMBL10485841 | 0.94 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL10485527 | 0.93 | PKM (0.48) | ALDH1A1LMNAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL128521 | 0.88 | CA12 (0.44) | ALDH1A1LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL9633444 | 0.84 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL9634069 | 0.84 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL9633418 | 0.83 | GAA (0.48) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL10484487 | 0.82 | ESR1 (0.44) | ALDH1A1LMNAMAPTHTTACHE | |
| SCHEMBL10598940 | 0.82 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL9634057 | 0.82 | GAA (0.45) | ALDH1A1LMNAMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315082-B1 | PROCESS FOR INCREASING THE ELECTROSTATIC CHARGEABILITY OF POWDER PAINTS OR POWDERS AND THEIR USE IN THE SURFACE COATING OF SOLID ITEMS | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-06 | — | — | EP | disclosed |
| US-5021473-A | With mixture of polymer(s) and catonic compound | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-06-04 | — | — | US | disclosed |