Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.59 |
| ▸ | TNKS | O95271 | 1/20 | 0.59 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.59 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633777 | 1.00 | NPSR1 (0.61) | NPSR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL69146 | 0.88 | NPSR1 (0.74) | NPSR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL271386 | 0.88 | NPSR1 (0.74) | NPSR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9633755 | 0.82 | HCAR2 (0.61) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9633762 | 0.82 | HCAR2 (0.61) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL27771748 | 0.82 | HDAC3 (0.79) | NPSR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2323106 | 0.81 | NPSR1 (0.65) | NPSR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2323099 | 0.81 | NPSR1 (0.65) | NPSR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7496018 | 0.80 | PKM (0.60) | NPSR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7496023 | 0.80 | PKM (0.60) | NPSR1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |