Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635034 | 0.93 | CYSLTR2 (0.62) | CYSLTR2CYSLTR1NAMPTRAB9AMEN1 | |
| SCHEMBL9635012 | 0.83 | CYP1A2 (0.46) | CYSLTR2CYSLTR1MEN1KMT2ACYP1A2 | |
| SCHEMBL9647175 | 0.79 | MAPT (0.44) | MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL9633653 | 0.79 | CYSLTR2 (0.60) | CYSLTR2CYSLTR1NAMPT | |
| Hydrochloric Acid SCHEMBL9635452 | 0.78 | MAPT (0.43) | RAB9AMEN1KMT2ANPC1HPGD | |
| SCHEMBL8951494 | 0.78 | CYSLTR2 (0.59) | CYSLTR2CYSLTR1NAMPT | |
| SCHEMBL9634219 | 0.78 | MEN1 (0.35) | CYSLTR2CYSLTR1NAMPTRAB9AMEN1 | |
| SCHEMBL8951243 | 0.78 | CYSLTR1 (0.71) | CYSLTR2CYSLTR1EPHX2 | |
| SCHEMBL9479571 | 0.77 | NAMPT (0.54) | CYSLTR2CYSLTR1NAMPTRAB9ANPC1 | |
| SCHEMBL8951199 | 0.77 | CYSLTR2 (0.87) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337765-B1 | ACYLSULFONAMIDE DERIVATIVES OF ALPHA-CARBOCYCLYLTOLUIC ACIDS USED AS LEUKOTRIENE ANTAGONISTS | ICI AMERICAS INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| US-5095038-A | Antiinflammatory, antiallergens | ICI AMERICAS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| EP-0337765-A2 | Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists | ICI AMERICAS INC. (US) | 1989-10-18 | — | — | EP | disclosed |